PHD2/prolylhydroxylase, EnkiLife, AMRe83982
Information about this antibody
Target
Vendor
Catalog No
AMRe83982
Application
Clonality
Recombinant
Origin
Rabbit
Reactivity
Human
Conjugation
N/A
Product Link
Product Name
PHD2/prolylhydroxylase Rabbit Monoclonal Antibody
Isotype
IgG
Accession
Q9GZT9
Concentration
0.68mg/ml. The concentration of this product may be batch-dependent.
Form
Liquid
Vendor notes
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.