FOXC1, EnkiLife, AMRe01997

DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed: 11782474, PubMed: 15299087, PubMed: 15684392, PubMed: 16492674, PubMed: 27907090, PubMed: 14506133, PubMed: 14578375, PubMed: 15277473, PubMed: 16449236, PubMed: 17210863, PubMed: 19793056, PubMed: 19279310, PubMed: 25786029, PubMed: 27804176). Acts either as a transcriptional activator or repressor (PubMed: 11782474). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed: 7957066, PubMed: 11782474, PubMed: 12533514, PubMed: 14506133, PubMed: 19793056, PubMed: 27804176). Upon DNA-binding, promotes DNA bending (PubMed: 7957066, PubMed: 14506133). Acts as a transcriptional coactivator (PubMed: 26565916). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification . Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed: 26565916). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed: 17993506). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity . Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed: 12408963). Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed: 20406990, PubMed: 22991501). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression . Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed: 27907090). Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression . May function as a tumor suppressor (PubMed: 12408963).