TRIM29, EnkiLife, AMRe84310
Information about this antibody
Target
Alt. Targets
Vendor
Catalog No
AMRe84310
Application
Clonality
Recombinant
Origin
Rabbit
Reactivity
Human, Mouse, Rat
Conjugation
N/A
Product Link
Product Name
TRIM29 Rabbit Monoclonal Antibody
Isotype
IgG
Accession
Q14134
Form
Liquid
Vendor notes
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.