GTF2B, EnkiLife, AMRe18810

General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II. General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (PubMed: 1876184, PubMed: 1946368, PubMed: 1517211, PubMed: 3818643, PubMed: 3029109, PubMed: 8413225, PubMed: 8515820, PubMed: 8516311, PubMed: 8516312, PubMed: 7601352, PubMed: 9420329, PubMed: 12931194, PubMed: 27193682). Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex (PubMed: 8504927, PubMed: 8413225, PubMed: 8515820, PubMed: 8516311, PubMed: 8516312). Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle (PubMed: 7601352). Associates with chromatin to core promoter-specific regions (PubMed: 12931194, PubMed: 24441171). Binds to two distinct DNA core promoter consensus sequence elements in a TBP- independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element (PubMed: 9420329, PubMed: 16230532, PubMed: 7675079, PubMed: 10619841). Modulates transcription start site selection (PubMed: 10318856). Exhibits also autoacetyltransferase activity that contributes to the activated transcription (PubMed: 12931194).