PTPN11, EnkiLife, AMRe06005

SHP-2 a SH2-containing a ubiquitously expressed tyrosine-specific protein phosphatase. It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens and extracellular matrices in the control of cell growth, differentiation, migration, and death. Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed: 10655584, PubMed: 18559669, PubMed: 18829466, PubMed: 26742426, PubMed: 28074573). Positively regulates MAPK signal transduction pathway (PubMed: 28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed: 28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed: 18559669). Dephosphorylates CDC73 (PubMed: 26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity).