IRF8, EnkiLife, AMRe02172
Information about this antibody
Target
Vendor
Catalog No
AMRe02172
Application
Clonality
Recombinant
Origin
Rabbit
Reactivity
Human
Conjugation
N/A
Product Link
Product Name
IRF8 Rabbit Monoclonal Antibody
Isotype
IgG
Accession
Q02556
Concentration
1mg/ml. The concentration of this product may be batch-dependent.
Form
Liquid
Vendor notes
Plays a role as a transcriptional activator or repressor (PubMed: 25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes .