CCND1, EnkiLife, AMRe09589

Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed: 1833066, PubMed: 1827756, PubMed: 8114739, PubMed: 8302605, PubMed: 19412162, PubMed: 33854235). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed: 1833066, PubMed: 1827756, PubMed: 8114739, PubMed: 8302605, PubMed: 19412162). Hypophosphorylates RB1 in early G(1) phase (PubMed: 1833066, PubMed: 1827756, PubMed: 8114739, PubMed: 8302605, PubMed: 19412162). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed: 1833066, PubMed: 1827756, PubMed: 8302605, PubMed: 19412162). Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity (PubMed: 15241418). Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed: 9106657). Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (PubMed: 16569215, PubMed: 18417529).