IGF2R, EnkiLife, AMRe13539

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed: 2963003, PubMed: 18817523). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed: 2963003, PubMed: 18817523). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed: 18817523). This receptor also binds IGF2 (PubMed: 18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed: 10900005).