PDPK1, EnkiLife, AMRe21117

Cell localization: Membrane, Cytoplasm. catalytic activity: ATP + a protein = ADP + a phosphoprotein. , function: Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive. , PTM: Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation. , similarity: Belongs to the protein kinase superfamily. , similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily. , similarity: Contains 1 PH domain. , similarity: Contains 1 protein kinase domain. , subcellular location: Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane. , subunit: Interacts with TUSC4. , tissue specificity: Appears to be expressed ubiquitously. ,