PIK3C3, EnkiLife, AMRe21086

Cell localization: Midbody . Late endosome . Cytoplasmic vesicle, autophagosome . As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed: 14617358). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). . . catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. , cofactor: Manganese. , function: Catalytic subunit of the PI3K complex. Involved in the transport of lysosomal enzyme precursors to lysosomes. , similarity: Belongs to the PI3/PI4-kinase family. , similarity: Contains 1 PI3K/PI4K domain. , subunit: Probably forms a complex with AMBRA1 and BECN1 (By similarity). Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. , tissue specificity: Ubiquitously expressed, with a highest expression in skeletal muscle. ,