RIPK1, EnkiLife, AMRe21588
Information about this antibody
Target
Alt. Targets
N/A
Vendor
Catalog No
AMRe21588
Application
Clonality
Recombinant
Origin
Rabbit
Reactivity
Human
Conjugation
N/A
Product Link
Product Name
RIP Rabbit Monoclonal Antibody
Isotype
IgG,Kappa
Accession
Q13546
Concentration
0.3mg/ml. The concentration of this product may be batch-dependent.
Form
Liquid
Vendor notes
Cell localization: Cytoplasmic, Membranous. catalytic activity: ATP + a protein = ADP + a phosphoprotein. , function: Promotes apoptosis and activation of NF-kappa-B. Required for TNFRSF1A mediated activation of NF-kappa-B. , PTM: Autophosphorylated on serine and threonine residues. , PTM: Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and enhances pro-apototic signaling through the TRADD-FADD interaction. , similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. , similarity: Contains 1 death domain. , similarity: Contains 1 protein kinase domain. , subunit: Binds to the death domain of TNFRSF6 and TRADD. Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RIPK3, UBCE7IP1 isoform 3 (ZIN), EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interacts with MAVS/IPS1. ,