ABCB1 MDR1 PGY1, EnkiLife, AMRe21283
Information about this antibody
Target
Alt. Targets
Vendor
Catalog No
AMRe21283
Application
Clonality
Recombinant
Origin
Rabbit
Reactivity
Human
Conjugation
N/A
Product Link
Product Name
MDR1 Rabbit Monoclonal Antibody
Isotype
IgG,Kappa
Accession
P08183
Concentration
0.3mg/ml. The concentration of this product may be batch-dependent.
Form
Liquid
Vendor notes
Cell localization: Membrane. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008],