CD19, EnkiLife, AMRe08254

CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin-like domains. Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed: 2463100, PubMed: 1373518, PubMed: 16672701). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed: 9382888, PubMed: 9317126, PubMed: 12387743, PubMed: 16672701). Is not required for early steps during B cell differentiation in the blood marrow (PubMed: 9317126). Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed: 2463100, PubMed: 1373518). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed: 9317126, PubMed: 12387743, PubMed: 16672701).