SIRT1, EnkiLife, AMRe06006
Information about this antibody
Target
Alt. Targets
Vendor
Catalog No
AMRe06006
Application
Clonality
Recombinant
Origin
Rabbit
Reactivity
Human
Conjugation
N/A
Product Link
Product Name
Phospho-SIRT1 (S47) (2Y6) Rabbit Monoclonal Antibody
Isotype
IgG
Accession
Q96EB6
Concentration
0.5mg/ml. The concentration of this product may be batch-dependent.
Form
Liquid
Vendor notes
The Silent Information Regulator (SIR2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as class III histone deacetylases. SirT1 deacetylase activity is inhibited by nicotinamide and activated by resveratrol. NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. During the neurogenic transition, represses selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation.