ACO1, EnkiLife, AMRe06511
Information about this antibody
Target
Alt. Targets
Vendor
Catalog No
AMRe06511
Application
Clonality
Recombinant
Origin
Rabbit
Reactivity
Human, Mouse, Rat
Conjugation
N/A
Product Link
Product Name
Aconitase 1 (7U6) Rabbit Monoclonal Antibody
Isotype
IgG
Accession
P21399
Concentration
0.5mg/ml. The concentration of this product may be batch-dependent.
Form
Liquid
Vendor notes
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed: 1946430, PubMed: 1281544, PubMed: 8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed: 1946430, PubMed: 1281544, PubMed: 8041788, PubMed: 23891004). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed: 1946430, PubMed: 1281544, PubMed: 8041788, PubMed: 23891004).