CTNNB1, EnkiLife, KVAb00077
Information about this antibody
Target
Alt. Targets
Vendor
Catalog No
KVAb00077
Application
Clonality
mAb
Origin
Mouse
Reactivity
Human, Mouse, Rat
Conjugation
N/A
Product Link
Product Name
KO-Validated Catenin Beta 1 Mouse Monoclonal Antibody
Isotype
Mouse IgG1
KO/KD-Validated
Yes
Accession
P35222
Purity
Affinity purification
Form
Liquid
Vendor notes
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]