Related topics: Alphabetical list, Membrane proteins, Neuroscience
On July 8, 2018
Camilla Gustafsen, Aarhus Universitet wrote:
Everaerts and colleagues, KU Leuven, published in 2009 a Short Communication paper in which they test three commercially available antibodies against transient receptor potential channel-vanilloid sub-family member-1 (TRPV1). In this paper, they study the immunohistochemical expression pattern of TRPV1 in bladder tissue from WT mice, using a TRPV1 knock out mouse as control.
Surprisingly, all tested antibodies, including this one, result in similar staining in WT and knock outs, indicating unspecific immunoreactivity of these antibodies in bladder tissue.
For further information:
Everaerts et al., “Where is TRPV1 expressed in the bladder, do we see the real channel?”
Naunyn Schmiedebergs Arch Pharmacol. 2009 Apr;379(4):421-5
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